期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 8, 页码 1948-1954出版社
AMER CHEMICAL SOC
DOI: 10.1021/np500465g
关键词
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资金
- National Natural Science Foundation of China [31370372, 31170323, 81001403]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China
- Program for Youth Chutian Scholar of Hubei Province of China
- Fundamental Research Funds for the Central Universities [HUST: 2014QN131]
Three new diterpenoids with unprecedented carbon skeletons, cinncassiols F (1) and G (2) and 16-O-beta-D-glucopyranosyl-19-deoxycinncassiol G (3), a new isoryanodane diterpenoid, 18-hydroxyperseanol (4), six known isoryanodane diterpenoids, 5-10, and a known ryanodane diterpenoid, 11, were isolated from the stem bark of Cinnamomum cassia. Compound 1 possesses an 11,13:12,13-diepoxy-6,11-epoxy:12,13-disecoisoryanodane diterpenoid skeleton bearing ketal and hemiketal functionalities, whereas compounds 2 and 3 feature an 11,12-secoisoryanodane diterpenoid skeleton with an 11,6-lactone moiety. The structures of the four new diterpenoids, 1-4, and their absolute configurations were established using HRESIMS, NMR, ECD, single-crystal X-ray diffraction, and chemical methods. Compounds 2 and 11 significantly inhibited the proliferation of murine T cells induced by ConA.
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