期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 7, 页码 1615-1623出版社
AMER CHEMICAL SOC
DOI: 10.1021/np5002303
关键词
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资金
- National Research Foundation of Korea (NRF) [NRF-2012R1A2A2A01009417]
- Procurement and Development of Foreign Biological Resources - Korean government [2012-K1A1A3307871]
During a search for SIRT1 activators originating in nature, three new dammarane triterpenes, 6 alpha,20(S)-dihydroxydammar-3,12-dione-24-ene (1), 6 alpha,20(S),24(S)-trihydroxydammar-3,12-dione-25-ene (2), and 6 alpha,20(S),25-trihydroxydammar-3,12-dione-23-ene (3), as well as two known triterpenes, dammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol (4) and 20(S)-ginsenoside Rg(3) (5), were isolated from Panax ginseng leaves. Compounds 1 and 3-5 showed potential as SIRT1 activators, as analyzed by in vitro enzyme-based SIRT1-NAD/NADH and SIRT1-p53 luciferase cell-based assays. They were also found to increase the level of NAD(+)/NADH ratio in HEK293 cells. This study presents a new class of chemical entities that may be able to be developed as SIRT1 activators for antiaging and treatment of age-associated diseases.
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