Weakly Anti-inflammatory Limonoids from the Seeds of Xylocarpus rumphii

Seven new limonoids, namely, xylorumphiins EJ (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (810), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 mu M, respectively.