期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 1, 页码 138-147出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400824u
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资金
- NSFC [30672607]
- National Hi-Tech 863-Projects [2010DFA31610, 2011AA090701, 2013AA092902]
- COMRA [DY125-15-T-01]
- Sino-German Project [GZ816]
Chemical examination of the solid culture of the endophytic fungus Stachybotrys chartarum isolated from the sponge Niphates recondita resulted in the isolation of 16 new phenylspirodrimanes, named chartarlactams A P (1-16), together with eight known analogues. Their structures were determined on the basis of extensive spectroscopic analysis, including X-ray single-crystal diffraction for the determination of the absolute configurations. The isoindolone-drimane dimer chartarlactam L (12) was determined as a new skeleton. Compounds 1-6 and 8-24 were evaluated for antihyperlipidemic effects in HepG2 cells, and the primary structure-activity relationships are discussed.
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