期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 4, 页码 963-968出版社
AMER CHEMICAL SOC
DOI: 10.1021/np401046z
关键词
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资金
- Japan Society for the Promotion of Science (JSPS)
- High-Tech Research Center Project, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [S0801043]
- Grants-in-Aid for Scientific Research [24590218] Funding Source: KAKEN
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.
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