期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 4, 页码 931-941出版社
AMER CHEMICAL SOC
DOI: 10.1021/np4010135
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资金
- National Natural Science Foundation of China [21322204, 81172939]
- NSFC-Joint Foundation of Yunnan Province [U1302223]
- Reservation-Talent Project of Yunnan Province [2011CI043]
- Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]
- West Light Foundation of the Chinese Academy of Sciences
Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E-V, 1-18), along with 17 known analogues (19-35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction analysis. The isolates were screened against five human tumor cell lines; compounds 3, 4, 9, 11-13, 23, 25-28, and 33 exhibited significant cytotoxic activity against all five, with IC50 values ranging from 0.4 to 5.1 mu M. In addition, 17 of the isolates strongly inhibited nitric oxide production in LPS-activated RAW264.7 macrophages.
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