期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 6, 页码 1396-1403出版社
AMER CHEMICAL SOC
DOI: 10.1021/np500156n
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资金
- Ministry of Oceans and Fisheries, Korea [PM 57561]
The suvanines, a new suvanine salt, five new (2, 4-8) and two known sesterterpenes from the same structural class, and two new modified lipids (9 and 10) were isolated from a Coscinoderma sp. sponge collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic and chemical analyses, a new suvanine salt was determined to be the suvanine N,N-dimethy1-1,3-dimethylherbipoline salt (2) and suvanine-lactam derivatives (4-8) formed by condensations between an oxidized furan moiety and amino adds. The lipid metabolites were found to be new derivatives of the taurine-containing deacyl irciniasulfonic acid class. The suvanines exhibited moderate cytotoxicities against the 1(562 and A549 cell lines, while the new suvanine salt (2) had significant antibacterial activity.
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