期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 6, 页码 1182-1186出版社
AMER CHEMICAL SOC
DOI: 10.1021/np300897v
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资金
- National Basic Research Program of China (973 Program) [2010CB833803]
- National Natural Science Foundation of China [41206130]
- National High Technology Research and Development Program of China (863 Program) [2012AA092104]
- National Marine Public Welfare Research Project of China [201305017]
- Chinese Academy of Sciences [5060267]
A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
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