期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 11, 页码 2065-2073出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400483c
关键词
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资金
- PRIN KFMP7Z Natural products and bioinspired molecules interfering with biological targets involved in control of tumor growth
- National Marine '863' Project [2013AA092902]
- Natural Science Foundation of China [21021063, 81273430, 21072204]
- SKLDR/SIMM Projects [SIMM1203ZZ-03, SIMM1105KF-04, SIMM1203KF-12]
- Fonds National de la Recherche Scientifique (FRS-FNRS, Belgium)
The isolation and structure elucidation of 10 unreported polypropionate metabolites (compounds 6-15), structurally related to either ilikonapyrone (1) or onchidione (3), from two onchidiid pulmonate mollusk species are discussed. Structure elucidation was achieved by NMR spectroscopy and chemical correlation with model compounds. Evaluation of in vitro growth-inhibitory properties in human cancer cells was also carried out on some of the isolated polypropionates including previously reported onchidione metabolites.
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