期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 11, 页码 2106-2112出版社
AMER CHEMICAL SOC
DOI: 10.1021/np4006647
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资金
- Specialized Research Fund for the Doctoral Program of Higher Education [20100132120026]
- National Natural Science Foundation of China [41176120]
- Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province [BS2010HZ027]
- Program for New Century Excellent Talents in University [NCET-12-0499]
- National High Technology Research and Development Program of China [2013AA092901]
- Public Projects of State Oceanic Administration [20104180223]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
Five new nitrogen-containing sorbicillinoids named sorbicillamines A-E (1-5) were isolated from an agitated culture of the deep-sea-derived fungus Penicillium sp. F23-2, which has previously produced indole alkaloids and terpenoids when cultured under static conditions. The structures of 1 to 5, including absolute configurations, were determined based on MS, NMR, and circular dichroism (CD) data. The c-ytotoxicities of the five new sorbicillin alkaloids against the HeLa, BEL-7402, HEK-293, HCT-116, and P388 cell lines were evaluated.
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