Trichinenlides A-T, Mexicanolide-Type Limonoids from Trichilia sinensis

Twenty new mexicanolide-type limonoids, namely, trichinenlides A T (1-20), and 11 known analogues were isolated from the leaves and twigs of Trichilia sinensis. Trichinenlides B (2) and C (3) and heytrijunolide D exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 2.85, 1.88, and 3.33 mu M, respectively.