Dibenzocyclooctadiene Lignans and Norlignans from Fruits of Schisandra wilsoniana

Seven new dibenzocyclooctadiene lignans, marlignans M S (1-7), four new norlignans, marphenols C F (8-11), and 21 known compounds (12-32) were isolated from the fruits of Schisandra wilsoniana. The structures of 1-11 were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and CD experiments. Compounds 1-11 were evaluated for their anti-HIV activities and showed EC50 values in the range 2.97-6.18 mu g/mL and therapeutic index values of 5.33-29.13.