期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 5, 页码 817-823出版社
AMER CHEMICAL SOC
DOI: 10.1021/np3004497
关键词
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资金
- American Cancer Society [RSG-06-011-01-CDD]
- NIH [T32 CA009523]
Spirohexenolides A and B comprise a unique family of spirotetronate natural products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity-fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.
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