期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 1, 页码 49-56出版社
AMER CHEMICAL SOC
DOI: 10.1021/np4005745
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资金
- BMBF
- Televie Luxembourg
- Waxweiler grant for cancer prevention research from the Action Lions Vaincre le Cancer
- Televie Luxembourg, the Recherche Cancer et Sang Foundation
- Recherches Scientifiques Luxembourg Association
- European Union [ITN Red Cat 215009]
- National Research Foundation (NRF)
- MEST of Korea for the Tumor Microenvironment Global Core Research Center (GCRC) [2012-0001184]
- Seoul National University
- Research Settlement Fund for the new faculty of SNU
A chemical investigation of the endophytic fungus Epicoccum nigrum isolated from leaves of Mentha suaveolens collected in Morocco resulted in the isolation of five new polyketides, epicocconigrones A and B (1 and 2), 3-methoxyepicoccone B (3), 3-methoxyepicoccone (4), and 2,3,4-trihydroxy-6-(methoxymethyl)-5-methylbenzaldehyde (5), together with five known compounds (6-10). The structures of the new compounds were unambiguously determined by extensive analysis of the 1D and 2D NMR and mass spectroscopic data. Compounds 1 and 10 showed potent inhibition of at least 15 protein kinases with IC50 values ranging from 0.07 to 9.00 mu M. Moreover, compounds 1 and 10 inhibited histone deacetylase (HDAC) activities with IC50 values of 9.8 and 14.2 mu M, respectively. A preliminary structure activity relationship is discussed. Interestingly, compounds 1 and 10 exert mainly cytostatic effects in human lymphoma RAJI and U-937 cell lines.
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