期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 9, 页码 1661-1667出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400372v
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资金
- National Science Council of Taiwan [NSC-100-2320-B-110-001-MY2]
- Aim for the Top University Program from the Ministry of Education of Taiwan [01C030205]
Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I-S (1-11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1-11 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). Compound 5 exhibited cytotoxicity toward several cancer cell lines. Compound 5 is the first eunicellin-based metabolite bearing a phenyl group and displays significant inhibition of both superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils.
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