Phthalide and Isocoumarin Derivatives Produced by an Acremonium sp Isolated from a Mangrove Rhizophora apiculata

Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and tricho-dermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.