期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 12, 页码 2049-2054出版社
AMER CHEMICAL SOC
DOI: 10.1021/np300544a
关键词
-
资金
- BK21 Program, Ministry of Education, Science and Technology
- Marine Biotechnology Program, the Ministry of Land, Transport and Maritime Affairs, Korea
Six new (1, 2, and 5-8) and three known (3, 4, and 9) butenolide metabolites were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 mu M. Cadiolides 5-9 in particular exhibited significant antibacterial activity that was comparable to or even better than those of marketed drugs such as vancomycin and linezolid against all of the drug-resistant strains tested.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据