期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 5, 页码 1001-1005出版社
AMER CHEMICAL SOC
DOI: 10.1021/np300147d
关键词
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资金
- Pfizer Global Research and Development
- Australian Research Council (ARC) [LE0668477, LE0237908]
A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-directed isolation of the CH2Cl2/CH3OH extract from S. ianthelliformis resulted in the purification of three new bromotyrosine-derived metabolites, ianthelliformisamines A-C (1-3), together with the known natural products aplysamine 1 (4) and araplysillin I (5). The structures of 1-3 were determined following analysis of 1D and 2D NMR and MS spectroscopic data. This is the first report of chemistry from the marine sponge S. ianthelliformis. Ianthelliformisamine A (1) showed inhibitory activity against the Gram-negative bacterium P. aeruginosa with an IC50 value of 6.8 mu M (MIC = 35 mu M).
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