期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 3, 页码 344-350出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200414c
关键词
-
资金
- National Science Foundation [9506620, CHE-9977213]
- NIH [R01CA139159, P20RR16455-04]
- NCRR [P20RR017670]
- [5P30NS055022]
- [RC2ES018742]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [9506620] Funding Source: National Science Foundation
Berkeley Pit Lake, Butte, Montana, is a 540 m deep abandoned open-pit copper mine filled with over 140 billion liters of acidic, metal-sulfate-contaminated water. This harsh environment has yielded several microorganisms that produce interesting biologically active compounds. Several polyketide metabolites including the new berkazaphilones A (1) and B (2) and octadienoic acid derivatives berkedienoic acid (13) and berkedienolactone (15), as well as previously reported azaphilone 4, vermistatin (6), dihydrovermistatin (7), penisimplicissin (8), aldehyde 9, and methylparaconic acid (11), were isolated from a culture broth of Penicillium rubrum taken from a depth of 270 m. The structures of these compounds were deduced by interpretation of spectroscopic data. The compounds were isolated either for their inhibition of the signal transduction enzyme caspase-1 or because of their structural similarity to these inhibitors. Selected compounds were further evaluated for their ability to inhibit interleukin-1 beta production by inflammasomes in induced THP-1 cells. Berkazaphilones B (2) and C (4) and vermistatin analogue penisimplicissin (8) exhibited selective activity against leukemia cancer cell lines in tha National Cancer Institute 60 human cell line assay.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据