期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 10, 页码 1744-1749出版社
AMER CHEMICAL SOC
DOI: 10.1021/np3004112
关键词
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资金
- National Natural Science Foundation [81121062, 81172948, 21132004, 30901846, 90813036, 21072092]
- New Century Excellent Talents in University [NCET-10-0477]
- Jiangsu Provincial Government [BK2009010]
- Ministry of Science and Technology of China [2011AA09070204]
- University of Malaya [UM.C/625/1/HIR/033/10]
A new sesquiterpenoid, diaporol A (1), V possessing a unique tricyclic lactone framework, eight new drimane sesquiterpenoids, diaporols B-I (2-9), and the known compounds 10 and 11 were isolated from a culture of the mangrove-derived endophyte Diaporthe sp. The absolute configurations of 1-5 were determined by low-temperature (100 K) single-crystal X-ray diffraction with Cu K alpha radiation. The compounds were evaluated for cytotoxic activity; however, no compound showed significant cytotoxicity against the tested cell lines at a concentration of 20 mu M.
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