期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 12, 页码 2094-2100出版社
AMER CHEMICAL SOC
DOI: 10.1021/np300520w
关键词
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资金
- Natural Sciences and Engineering Council of Canada (NSERC)
- Canada Research Chair Program
- University of Prince Edward Island
- Atlantic Innovation Fund
- Jeanne and Jean-Louis Levesque Foundation
Four new steroidal glycosides, acanthifoliosides G-J (1-4), were isolated as minor constituents from the Caribbean marine sponge Pandaros acanthifolium. These metabolites are characterized by a highly oxygenated D ring and the presence of a disaccharide rhamnose-glucose residue and a rhamnose at positions C-3 and C-is, respectively. Their structures were established on the basis of extensive interpretation of ID and 2D NMR data and HRESIMS analyses. The absolute configurations of the glucose and rhamnose sugars were determined by preparing aldose o-tolylthiocarbamate derivatives and comparison to authentic standards by LC/HRESIMS. Acanthifolioside G (I) exhibited antioxidant and cytoprotective activities.
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