期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 9, 页码 1648-1651出版社
AMER CHEMICAL SOC
DOI: 10.1021/np3003854
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资金
- National Cancer Institute, NIH [R37CA044848]
- Korea Institute of Science and Technology [2Z03550]
- National Research Council of Science & Technology (NST), Republic of Korea [2Z0355] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A new lucentamycin analogue, lucentamycin E (5), was isolated from the culture broth of the marine-derived actinomycete Nocardiopsis lucentensis, strain CNR-712. The absolute stereostructure of 5 was assigned by comprehensive analyses of NMR data and by application of the advanced Marfey's method. The planar structure of 5 was analogous to lucentamycins A-D, whereas the olefin geometry of the 3-methyl-4-ethylideneproline moiety was found to be E, opposite of that previously reported. Consequently, a reinvestigation of the olefin geometries of the 3-methyl-4-ethylideneproline residues of lucentamycins A-D showed that the olefin geometries of the substituted proline functionalities must be revised to (2S,3R,E)-3-methyl-4-ethylideneproline.
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