期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 9, 页码 1656-1659出版社
AMER CHEMICAL SOC
DOI: 10.1021/np300475d
关键词
-
资金
- Natural Science Foundation of China [41076082, 81172979]
Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3 beta(beta-xylopyranosyloxy)-5 alpha-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2.
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