期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 4, 页码 871-876出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1008015
关键词
-
资金
- NIH, NIGMS [P41GM806210]
Malyngamide 3 (1) and cocosamides A (2) and B (3) were isolated from the lipophilic extract of a collection of Lyngbya majuscula from Cocos,Lagoon, Guam. The planar structures of compounds 1-3 were determined by spectroscopic methods. The absolute configuration of 1 was determined by modified Mosher's method, NOESY data, and comparison with lyngbic acid (4). The absolute configurations of 2 and 3 were assigned by enantioselective HPLC analysis and comparison with the closely related compound pitipeptolide 4 (5). Compounds 173 showed weak cytotoxicity against MCF7 breast cancer and HT-29 colon cancer cells.
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