Bioactive Sesqui- and Diterpenoids from the Argentine Liverwort Porella chilensis

Four fusicoccane-type diterpenoids (1-4), in cluding the new 1 and 2) four pinguisane-type sesquiterpenoids (5-8); and two aromadendrane type sesquiterpenoids (9 and 10) were isolated from an Argentine collection of the endemic liverwort Porella chilensis. The biofilm formation of the human pathogen Pseudomonas aeruginosa was inhibited by compounds 3 (53 and 47%);9, (45 and 41%), and 10 (48 and 37%) at 50 and; 5 mu g/mL respectiyely Compounds 1; 9, and 10 also produced a slight decrease in bacterial growth., and interfere with the process of quorum sensing at the Same doses.