期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 3, 页码 496-511出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100550t
关键词
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资金
- Fogarty International Center, the National Cancer Institute
- National Science Foundation
- National Heart, Lung and Blood Institute
- National Institute of Mental Health
- Office of Dietary Supplements
- Office of the Director of NIH [U01 TW000313]
- National Research Initiative of the Cooperative State Research, Education and Extension Service, USDA [2008-35621-04732]
Natural products continue to provide a diverse and unique source of bioactive lead compounds for drug discovery, but maintaining their continued eminence as source compounds is challenging in the face of the changing face of the pharmaceutical industry and the changing nature of biodiversity prospecting brought about by the Convention on Biological Diversity. This review provides an overview of some of these challenges and suggests ways in which they can be addressed so that natural products research can remain a viable and productive route to drug discovery. Results from International Cooperative Biodiversity Groups (ICBGs) working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery.
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