Marinoquinolines A-F, Pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes)

Marinoquinoline A (1) was. isolated from the gliding bacterium Ohtaekwangia kribbensis together with the novel marinoquinolines B-F (2-6) Their structures were elucidated from NMR and HRESIMS data. The pyrroloquinolines. showed, weak antibacterial and antifungal activities and, Moderate cytotoxicity against four growing mammalian cell lines with 1050 values ranging from 0.3 to 8:0 mu g/mL. In a screening against tropical parasites marinoquinolines A-F (1-6) showed, activity against Plasmodium falciparum K1 with IC(50) values, between 1.7 and 15 mu M.