期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 5, 页码 1230-1235出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200164k
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资金
- National Natural Science Foundation of China [20772162, 20972197]
- 863 Foundation of China [2006AA09Z422]
- Natural Science Foundation of Guangdong Province of China [9151027501000055]
- Science & Technology Plan Project of Guangdong Province of China [201013030600004]
- Fundamental Research Funds for the Central University of China [11lgjc01]
Four new norsesquiterpene peroxides, named talaperoxides A-D (1-4), as well as one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by ID and 2D NMR Structures of 1, 2, and 5 were further confirmed by single-crystal X-ray diffraction, and their absolute configurations were also determined using copper radiation. Cytotoxic activities of compounds 1-5 were evaluated in vitro against human cancer cell lines MCF-7, MDA-MB-435, HepG2, HeLa, and PC-3. Compounds 2 and 4 showed cytotoxicity against the five human cancer cell lines with IC(50) values between 0.70 and 2.78 mu g/mL.
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