期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 7, 页码 1653-1657出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200255f
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资金
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Division of Cancer Treatment and Diagnosis of the National Cancer Institute
Co-culture of the fungus Aspergillus fumigatus with the bacteria Streptomyces peucetius led to the induction of production of formyl xanthocillin analogues. This mixed fermentation yielded two new metabolites, fumiformamide (1) and N,N'-((1Z,3Z)-1,4-bis(4-methoxyphenyl)buta-1,3-diene-2,3-diyl)diformamide (2), together with two known N-formyl derivatives and the xanthocillin analogue BU-4704. The structures were determined by spectroscopic methods and by comparison with literature. Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity.
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