期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 7, 页码 1597-1605出版社
AMER CHEMICAL SOC
DOI: 10.1021/np2002226
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资金
- NCI/NIH [PO1 CA125066]
Four cyclic decapeptides, minutissamides A-D (1-4), were isolated from the cultured cyanobacterium Anabaena minutissima (UTEX 1613). The planar structures were determined using various spectroscopic techniques including HRESIMS and 1D and 2D NMR experiments. The absolute configurations of the alpha-amino acid residues were assigned using Marfey's method after acid hydrolysis. The absolute configuration of a beta-amino acid residue was assigned by a combination of the advanced Marfey's method, J-based configurational analysis, and ROE spectroscopic analysis. The structures of minutissamides A-D (1-4) were characterized by the presence of three nonstandard a-amino acid residues (two alpha,beta-dehydro-alpha-aminobutyric acids and one N-methylated Asn) and one beta-amino acid residue (2-hydroxy-3-amino-4-methyldodecanoic acid or 2-hydroxy-3-amino-4-methylhexadecanoic acid). Minutissamides A-D (1-4) exhibited antiproliferative activity against the HT-29 human colon cancer cell line with IC50 values of 2.0, 20.0, 11.8, and 22.7 mu M, respectively.
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