期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 10, 页码 2282-2285出版社
AMER CHEMICAL SOC
DOI: 10.1021/np2004227
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资金
- Egyptian Government
- Deutsche Forschungsgemeinschaft [FOR 845]
The marine endophytic fungus Coniothyrium cereale produces the structurally unusual polyketide-type alkaloids (-)-cereolactam (1) and (-)-cereoaldomine (3), incorporating a lactam and an imine functionality, respectively, as well as the related metabolite (-)-trypethelone (2). Compounds 1 and 3 showed selective inhibition of human leukocyte elastase with IC(50) values of 9.28 and 3.01 mu M, respectively. Compound 2 was found to be inhibitory toward Mycobacterium phlei, Staphylococcus aureus, and Escherichia coli and also cytotoxic against mouse fibroblast cells (IC(50) = 7.5 mu M).
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