期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 3, 页码 378-382出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100738m
关键词
-
资金
- Foundation for Research Support of the State of Sao Paulo, FAPESP [01/14243-5, 07/56525-3, 06/02892-2, 08/01988-1, 09/08089-5]
- National Counsel of Technological and Scientific Development, CNPq [563874/2005-8]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/08089-5] Funding Source: FAPESP
A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors:
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
