期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 12, 页码 2532-2544出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200635r
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资金
- Kansas Bioscience Authority (KBA) [IND 0061464]
- Center for Heartland Plant Innovations (HPI)
- Institute for Advancing Medical Innovation (IAMI) [NFP0066367]
- University of Kansas Center for Cancer Experimental Therapeutics NIH-COBRE [P20 RR015563]
- NSF [CHE-0923449]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0923449] Funding Source: National Science Foundation
Fourteen new withanolides, 1-14, named withalongolides A-N, respectively, were isolated from the aerial parts of Physalis longifolia together with eight known compounds (15-22). The structures of compounds 1-14 were elucidated through spectroscopic techniques and chemical methods. In addition, the structures of withanolides 1, 2, 3, and 6 were confirmed by X-ray crystallographic analysis. Using a MTS viability assay, eight withanolides (1, 2, 3, 7, 8, 15, 16, and 19) and four acetylated derivatives (1a, 1b, 2a, and 2b) showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986), melanoma (B16F10 and SKMEL-28), and normal fetal fibroblast (MRC-5) cells with IC50 values in the range between 0.067 and 9.3 mu M.
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