期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 9, 页码 1952-1958出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200452m
关键词
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资金
- RF [NSS 3531.2010.4]
- Presidium of RAS
- RFBR [09-04-00015-a]
- Ministry of Land, Transport and Maritime, Republic of Korea [PM56091]
New unusual polycyclic guanidine alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine sponge Monanchora pulchra. Their structures were established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC(50) values of 540, 200, 110, 830, and 650 nM, respectively.
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