期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 10, 页码 2290-2294出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200491g
关键词
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资金
- Thailand Graduated Institute of Science and Technology (TGIST)
- BIOTEC
- Hitachi Scholarship Foundation
- Higher Education Research Promotion and National Research University of Thailand, Office of the Higher Education Commission [AS613A]
As part of our ongoing efforts to investigate natural products with potential for use as cancer treatments, we have recently disclosed the cytotoxicity of unique norchamigrane (1) and chamigrane (2, 3) endoperoxides from a Thai mangrove-derived fungus. Reinvestigation of this fungus in a large-scale fermentation led to the isolation of an additional new chamigrane endoperoxide (4) and one known analogue (5). Among these isolated metabolites, compound 3 (merulin C) exhibited potent antiangiogenic activity mainly by suppression of endothelial cell proliferation and migration in a dose-dependent manner, and its effect is mediated by reduction in the phosphorylation of Erk1/2. Merulin C also displayed promising activity in a rat aortic ring sprouting (ex vivo) and a mouse Matrigel (in vivo) assay.
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