期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 5, 页码 1255-1261出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200231u
关键词
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资金
- National Natural Science Foundation [81021062, 20932007]
- National Science and Technology Major Project Key New Drug Creation and Manufacturing Program of the People's Republic of China [2009ZX09301-001]
Nine new daphnane-type diterpenoids (1-9), named trigohownins A-I, and four known analogues were isolated from Trigonostemon howii. Their structures were elucidated on the basis of extensive NMR and MS analyses. Trigohownins A (1) and D (4) exhibited moderate cytotoxic activity against the HL-60 tumor cell line, with IC(50) values of 17.0 and 9.3 mu M, respectively.
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