期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 5, 页码 1028-1035出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1009288
关键词
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资金
- NSFC [30830115, 20902093]
- Science and Technology Program of Yunan Province [2008GA031]
- Major State Basic Research Development Program of China [2009CB522300, 200940900]
- Western Doctoral Foundation of Chinese Academy of Sciences [KZCX2-XB2-15]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China [2009ZX09301-001, -063]
Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ana iosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.
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