Bathymodiolamides A and B, Ceramide Derivatives from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus thermophilus

Two ceramide derivatives, bathymodiolamides A (1) and B (2), were isolated from the deep-sea hydrothermal vent. invertebrate mussel Bathymodiolus thermophilus. The molecular structures of these compounds were determined using a:combination Of NMR spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed in a ApopScreen cell based screen for apoptosis induction and potential anticancer. activity. To our knowledge, this is the first report of secondary metabolites from the Marine hydrothermal vent-mussel B. thermophilus.