期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 1, 页码 95-98出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1005407
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资金
- NIH [CA 52955, NS 053398]
- NATIONAL CANCER INSTITUTE [U01CA052955, U19CA052955] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS053398] Funding Source: NIH RePORTER
A Papua New Guinea collection of the marine cyanobacterium cf. Lyngbya sordida yielded three known compounds as well as a new PKS-NRPS-derived malyngamide with anti-inflammatory and cytotoxic activity. Malyngamide 2 features an extensively oxidized cyclohexanone ring. Resolution of the ring core as a 6,8,9-triol rather then a 7,8,9-triol and relative configuration was based on chemical shift and bond geometry modeling in conjunction with homonuclear and heteronuclear coupling constants, NOE and ROE correlations, and other structural information. Malyngamide 2 exhibited anti-inflammatory activity in LPS-induced RAW macrophage cells (IC50 = 8.0 mu M) with only modest cytotoxicity to the mammalian cell line.
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