期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 11, 页码 2467-2471出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200589n
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资金
- National Museum of Marine Biology Aquarium [NMM98001]
- National Science Council of Taiwan [NSC-98-2113-M-110-002-MY3]
- Ministry of Education of Taiwan [98C031702]
Eight new eunicellin-based diterpenoids, klymollins A-H (1-8), were isolated during the chemical investigation of the soft coral Klyxum molle from Taiwan waters:. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 4 was determined by Mosher's method. Bioassays of the new metabolites showed that compounds 3-8 displayed significant in vitro anti-inflammatory activity by inhibiting the expression of the iNOS protein, and compounds 3, 4, and 6-8 also could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
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