期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 7, 页码 1613-1620出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200241c
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-
资金
- Ministry of Science and Technological Development of Serbia [172053, 41031]
From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
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