期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 8, 页码 1826-1829出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200350b
关键词
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资金
- Ministry of Land, Transport, and Maritime Affairs
- National Research Foundation, Korea [20090083538]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [20046003] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [KGM0231133] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Pour new polyketides (1-4) were isolated from the fungus Paecilomyces variotii, which was derived from the jellyfish Nemopilema nomurai. The planar structures and relative configurations of these polyketides were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. The compounds showed inhibitory activity against pathogenic bacteria including methicillin-resistant Staphylococcus aureus 3089 and multi-drug-resistant Vibrio parahemolyticus 7001 with MIC values in the range 5-40 mu g/mL.
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