期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 5, 页码 1275-1280出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1006795
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资金
- NIH, National Cancer Institute, Center for Cancer Research
Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.
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