Seco-eremophiladiolides and Eremophilane Glucosides from Pittocaulon velatum

Two seco-eremophiladiolides, velatumolide (1) and epi-velatumolide (2), the trihydroxyfuranoeremophilane velatumin (3), and three eremophilane glucosides (4-6) were isolated from Pittocaulon velatum, together with several known compounds. The structures of these compounds were elucidated by spectroscopic analysis and chemical reactions. The anti-inflammatory activity of the isolated compounds was investigated using the TPA-induced ear edema model.