期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 5, 页码 1005-1007出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100103j
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资金
- Chulalongkorn University
- Thailand Graduate Institute of Science and Technology (TGIST)
- Bioresource Research Network (BIOTEC)
- Center for Petroleum, Petrochemicals, and Advanced Materials
- Thai Government Stimulus Package [TKK2555]
A new nor-chamigrane endoperoxide, merulin A (1), and two new chamigrane endoperoxides, merulins B and C (2, 3), were isolated from the culture broth extract of an endophytic fungus of Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic, mainly NMR and MS, data. X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines.
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