An Antimycobacterial Cyclodepsipeptide from the Entomopathogenic Fungus Ophiocordyceps communis BCC 16475

A novel cyclodepsipeptide, cordycommunin (1), and two dihydroisocoumarins (2 and 3) were isolated from the insect pathogenic fungus Ophiocordyceps communis BCC 16475. The absolute configurations of the amino acid residues of I were addressed by application of Marfey's method. Cordycommunin (1) showed growth inhibition of Mycobacterium tuberculosis H37Ra with an MIC Value Of 15 mu M. This compound also exhibited weak cytotoxicity to KB cells with an IC50 of 45 mu M, while it was inactive against BC, NCI-H187, and Vero cell lines at a concentration of 88 mu M (50 mu g/mL).