期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 11, 页码 1947-1950出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1003565
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资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [16073207]
- Grants-in-Aid for Scientific Research [16073207] Funding Source: KAKEN
Five sphingoid bases, penasin A (1), penasin B (2), and a mixture of penasins C-E (3-5), were identified from a marine sponge Penares sp. as cytotoxic constituents. The structure of the common polar head part was assigned by analysis of the NMR data, whereas the structures of the long aliphatic chains including the locations of double bond(s) and a branched methyl group were determined by analysis of tandem FABMS and C-13 NMR data together with the GC-MS analysis of ozonolysis products. The absolute configuration of the headgroup was defined for the mixture of 3-5 by the modified Mosher method. Penasins exhibit moderate cytotoxicity against HeLa and P388 cells.
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