期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 5, 页码 880-884出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900843b
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资金
- NIH-INBRE
- College of Pharmacy
- American Society of Pharmacognosy
Bioassay-directed fractionation of the butanol extract of Streptomyces sp. L-4-4, using the hyphae formation inhibition assay of a prokaryotic whole cell, led to the isolation of six new aminocoumarins, coumabiocins A-F (1-6), along with two known compounds, novobiocin (7) and isonovobiocin (8). Coumabiocins A-E (1-5) contain three structural elements, a central 3-amino-7-hydroxycoumarin that is linked at the 3-amino group to a prenylated 4-hydroxybenzoic acid moiety and at the 7-position to an L-noviosyl sugar, while coumabiocin F (6) lacks the sugar moiety. Their structures were elucidated by spectroscopic methods including ID- and 2D-NMR techniques and mass spectrometric analyses. Coumabiocins A-E (1-5) exhibited significant inhibitory activity against Streptomyces 85E and gave a 10-15 mm clear zone of inhibition at 20 mu g/disk and a 10 mm bald and a 10 mm clear zone of inhibition at 5 and 10 mu g/disk, respectively, whereas coumabiocin F (6) was inactive.
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