期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 5, 页码 806-810出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900642p
关键词
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资金
- National Natural Science Foundation of China [30901849, 30700015]
- MOST [2007DFB31620]
- 863 Hi-Tech Research and Development Program of China [2006AA09Z402, 2007AA09Z443]
- Guang-dong Province [2006A50103001]
- Chinese Academy of Sciences [KSCXZ-YW-G-013, KSCX2-YW-R-164]
- National Science Technology [200703295000-02]
- Important National Science Technology [2008ZX09401-005]
- Hundred Talents Program
Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 mu g/mL ketoconazole.
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