期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 4, 页码 712-715出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900526y
关键词
-
资金
- NIH [2U19-CA529955]
- NATIONAL CANCER INSTITUTE [U19CA052955] Funding Source: NIH RePORTER
Bioactivity-guided fractionation of metabolites from the crinoid Holopus rangii led to the discovery of two new phenanthroperylenequinone derivatives, gymnochromes E (1) and F (2). Gymnochrome E showed cytotoxic activity toward the NCI/ADR-Res with an IC50 of 3.5 mu M. It also inhibited histone deacetylase-1 with an IC50 of 3.3 Gymnochrome F was a moderate inhibitor of myeloid cell leukemia sequence 1 (MCL-1) binding to Bak. Two anthraquinone metabolites, emodic acid (4) and its new bromo derivative (5), were also isolated from the crinoid and show remarkable similarity to the phenanthroperylenequinone core, suggesting that these metabolites share the same polyketide biosynthetic pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据